![]() Ending the unified origin trial: The Privacy Sandbox Relevance and Measurement origin trial ends on Septemproviding overlap with the transition to general availability.Gradually enabling the APIs: APIs will be gradually enabled over the course of the 115 milestone while monitoring for issues, aiming for 99% availability by mid-August.What's shipping: The launch process for the relevance and measurement APIs: Topics, Protected Audience, Attribution Reporting, Private Aggregation, Shared Storage, and Fenced Frames.In this post, we'll cover the multiple components of this launch, including: That moment is now here, so with Chrome 115 going to Stable, we are beginning the process of gradually enabling the APIs in the next few days. Epub 1.In May we shared our plans to ship the Privacy Sandbox relevance and measurement APIs in Chrome 115. Transcutaneous bilirubinometry: effect of postnatal age. ![]() Using BiliCheck for preterm neonates in a sub-intensive unit: diagnostic usefulness and suitability. De Luca D, Zecca E, de Turris P, Barbato G, Marras M, Romagnoli C. Archives of Disease in Childhood - Fetal and Neonatal Edition. Transcutaneous bilirubinometry in neonatal intensive care units. Transcutaneous Bilirubinometry: Nova Science Publishers, Incorporated 2013.Ģ. Simple stratification by age is more informative than regression analysis as the best site for TcB measurement may be dynamic.ġ. A study (reference # 19) has shown that the most reliable anatomical site for TcB measurements progressed cephalocaudally (forehead, right upper chest, mid-sternum) as postnatal age advanced.(4) The present study shows that anatomical sites have no effect in a regression analysis for other variables including age. However, it would be more informative if authors have presented the accuracy of TcB among G6PD-deficient newborns as this is the "real world" for populations with high prevalence of this disease. On average, TcB was higher than TSB in G6PD-def by 76 mmol/L (95% CI: 60-91, SD 44) and in G6PD-normal group by 88 mmol/L (95% CI: 78-98, SD 40). Correlation between TcB and TSB was 0.75 in G6PD-def vs. Retrospectively, we compared 34 TcB- TSB pairs of newborns with G6PD-def with that of 66 TcB-TSB pairs of G6PD- normal newborns. Contrary, we have found that accuracy of TcB was comparable in G6PD-deficient and normal newborns (unpublished data). Consequently, transcutaneous bilirubinometers control for hemoglobin effect.(1) Notably, these devises uses different method to eliminate the hemoglobin effect which may contribute to the observed superiority of one devise over the other in this study.(1) Research wise, it has been shown that hemoglobin levels have no effect on TcB measurement.(2, 3) If this authors' speculation is correct then TcB is expected to be less accurate among newborns with an exaggerated decline in hemoglobin levels such as glucose-6-phosphate dehydrogenase (G6PD) deficiency. Hemoglobin is one of chromophores that confounds TcB measurement.(1) Theoretically, correlation between TcB and TSB is expected to improve at lower levels of hemoglobin. In my opinion, physiological decrease in hemoglobin levels cannot be a contributing factor. ![]() It has been speculating that physiological decline in hemoglobin levels may be one of contributing factors to this finding. It has been found that correlation between transcutaneous bilirubin (TcB) and total serum bilirubin (TSB) decreases as postnatal age advances. ![]()
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